zvigadzirwa
Tetracaine hydrochloride
Product details
MF: C15H25ClN2O2
MW: 300.82
CAS: 136-47-0
1.Tetracaine hydrochloride inoshanda zvakanyanya yenzvimbo yekutindivadza iyo inogona kuvharira tsinga kushanda ichidzorereka.Inoshandiswa mukupinda anesthesia, nerve block anesthesia, epidural anesthesia, nezvimwewo zvichienzaniswa neprocaine, maitiro ayo emunharaunda anesthesia inokosha, uye yakashandiswa zvakanyanya mukiriniki.Kuburikidza nekudzidza nzira dziripo dzekugadzira, zvinoonekwa kuti kuumbwa kwepakati p-butylamino benzoic acid ndiro danho rinokosha mukugadzirwa kwe tetracaine hydrochloride, iyo ine kukanganisa kwezvinhu zvisina kugadzikana kana goho rakaderera.Vesainzi vakavandudza izvi.Muna 1981, vakaronga kugadzira p-butylamino benzoic acid ne alkylating p-aminobenzoic acid ne 1-Bromobutane.Nekudaro, nekuda kweiyo isingadzivisike kuumbwa kwe-zvigadzirwa zve dibutylation uye kusagadzikana hunhu hwezvigadzirwa, iyi nzira haina kukodzera kugadzirwa kwemaindasitiri.
2.Tetracaine hydrochloride inoshandiswa mucosal surface anesthesia, conduction anesthesia, epidural anesthesia uye subarachnoid anesthesia;Inoshandiswa kune ophthalmic surface anesthesia, haibatisi tsinga dzeropa, haikuvadzi corneal epithelium, uye haiwedzere intraocular pressure.
3. Mushonga uyu unogona kuwedzera nerve block effect ye cisatracurium, uye chiyero chekupedzisira chinofanira kuderedzwa kana chasanganiswa.Kana yasanganiswa neadrenaline, inogona kukanganisa tsinga dzeropa, kuderedza kuyerera kweropa, kunonoka kutora zvinodhaka, uye kurebesa nguva yekuita.Asi kusanganiswa kwezviviri hazvina kukodzera kuvarwere vane chirwere chemwoyo, hypertension, hyperthyroidism, peripheral vascular disease nezvimwe zvakadaro.Hyaluronidase inogona kubudirira kuwedzera kupararira kwechirwere ichi, kukurumidza kutanga kweanesthesia, kuderedza kuzvimba kwenharaunda, uye kudzivirira kuumbwa kwehematoma.Zvisinei, hyaluronidase inogonawo kukurumidzira kutorwa kwechirwere ichi, zvichikonzera kuwedzera kwe anti chemical Book toxicity yemushonga uyu.Mushonga uyu unobva pa p-aminobenzoic acid (PABA).Sulfonamides inoshandisa antibacterial effect nekudzivisa PABA yebhakitiriya.Kana ichi chinodhaka chakabatanidzwa ne sulfonamides, antibacterial effect yekupedzisira ichadziviswa, saka iyo miviri haifaniri kusanganiswa.Mushonga uyu une acidic uye haufanirwe kusanganiswa nealkaline liquid mushonga;Kunyange mishonga ine acidic inogona kukanganisa kukosha kwekuparadzanisa kwemushonga nekuda kwepH yakasiyana, zvichikonzera kuderedzwa kwekuita kana kunonoka kutanga nguva.Kugadzirira iodine kunogona kukonzera kunaya kwemushonga uyu, saka nzvimbo yejekiseni yemushonga uyu haigone kushandiswa.
Application
Ichi chigadzirwa chinotora nguva refu ester local anesthetic.Maitiro ayo ekuita ndeaya: kupindira kwakasimba kune mucosa, yakakodzera kune anesthesia yepamusoro, uye hapana maitiro asina kunaka akadai sevasoconstriction, mydriasis, kukuvara kwekorneal mushure mekudonha kweziso.Inonyanya kushandiswa mune ophthalmology.Iyo yemuno anesthetic effect uye chepfu inokwana kagumi kupfuura procaine.Mushure mejekiseni, iyo anesthetic effect yechemicalbook inoonekwa zvishoma nezvishoma (anenge maminetsi gumi), uye metabolism inononoka zvakare mushure mekutora.Nguva yeanesthesia yemunharaunda inosvika 3ij, h, -j.nezve.Rinonyanya kushandiswa pamusoro pekutindivadza ziso, mhino uye huro mucosa, uye kashoma kushandiswa conduction yokutindivadza uye epidural yokutindivadza.Kazhinji, haishandiswe kupinza anesthesia nekuda kwehupfu hwayo.
